Heart disease is the No. 1 cause of death for women throughout the world. Approximately seven times more women die from heart disease than breast cancer. Even in women with breast cancer, dying from heart disease is a leading cause of death.

Yet when I ask undergraduate students in my class (majority of whom are female) which disease causes the most deaths in women, only about half give the answer; heart disease. A third say it is breast cancer. This is similar to surveys, which found that only 56 per cent of women identified heart disease as the leading cause of death.

Such a lack of awareness has very real consequences. Women who experience a heart attack are more likely to misunderstand the symptoms and delay seeking treatment. According to the 2018 Heart Report from the Canadian Heart and Stroke Foundation early heart attack signs were missed in 78 per cent of women

Upon arrival in hospital, women’s symptoms can be dismissed by medical staff as something else. They are also referred less for treatments such as angioplasty (the clearing of a blockage in a heart artery) than men. A similar bias exists among general physicians resulting in less accurate diagnosis and treatment for women, and possibly greater risk for death.

So, why this dismal knowledge of heart disease in women?

One reason is that research has historically been conducted in middle-aged and older men. This is, in part, because men had heart attacks during their working years, potentially limiting their economic productivity. Women, who tended to suffer heart disease at a later age, received much less attention.

There was also a fear of involving pregnant women in research, which led to all women of child-bearing age being restricted from participating in most research in the U.S. until the 1990s.

This bias is easily recognized by the term “widowmaker” to describe the left main artery; one of the key arteries of the heart in which a blockage may lead to early death. As a result, people both within and outside the medical profession had the impression that heart disease only effects men.

The second reason for our general lack of understanding of heart disease in women is due to differences in biology. We now know that the findings from research in men don’t fully apply to women given differences in risk for heart disease and in anatomy.

As women get heart disease later in life than men, they also have other conditions such as diabetes, which makes treatment more complex. Women with diabetes have a 44 per cent greater risk for heart disease than men. In addition, gestational diabetes (which occurs during pregnancy and impacts approximately 5.5 per cent of births in Canada), is associated with a higher risk for heart disease compared to women who haven’t had gestational diabetes.

And differences extend to anatomy. Given their smaller body size, women tend to have smaller hearts and arteries than men. This has been associated with higher mortality during bypass surgery. Smaller arteries also make diagnostic techniques like the electrocardiogram (ECG) and coronary angiography (X-ray imaging of heart arteries) more challenging.

One of the more perplexing facts about heart disease in women is that a heart attack can occur even without any heart arteries being blocked. This can happen with a “coronary artery spasm,” in which an artery of the heart suddenly closes upon itself. And it can happen with “spontaneous coronary artery dissection,” in which the inside of the heart artery tears, leading to a blood clot.

When there is no blockage, diagnosis by traditional methods is difficult.

While women having a heart attack can feel severe pain in their chest, many also experience more subtle symptoms such as shortness of breath, discomfort in their arms, neck and jaw, sweating or nausea.

Despite these symptoms being fairly common in women, they are still referred to as “atypical,” indirectly suggesting that a woman’s experience is not normal. But they are normal for women.

While there is much work to be done, each year this gap in knowledge and treatment closes thanks in part to Health Canada and the US Food and Drug Administration implementing guidelines to ensure the inclusion of women in research.

Continued advocacy by the Heart and Stroke Foundation and the American Heart Association is also important for increasing awareness both within and outside of the health care systems. Additionally, more research in tailoring treatments to women, like female-only cardiac rehabilitation, will help us learn how to best treat women.

As individuals, the capacity to recognize and understand the signs and symptoms of heart disease could be life-saving — for our loved ones, friends, bystanders and even ourselves.

This article, by Dr. Scott Lear, was originally published on The Conversation. Read the original article.

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